Ondansetron HCI (Zofran)

CLASS:

• Antiemetic

• Serotonin Type 5-HT3 receptor antagonist

ACTION:

• Serotonin Type 5-HT3 receptor sites in chemoreceptors of the medulla and peripherally on vagal nerve terminals

INDICATION:

• prevent nausea and vomiting

CONTRAINDICATION:

• Hypersensitivity

STANDARD PREP: 4mg / 2ml

DOSAGE/ROUTE: 4 mg IV (repeat if no effect in 5 minutes) for adults and children > 10 kg

Onset: Rapid. Peak: 15-30 min Duration: 4-8 hr

PEDIATRIC DOSE:

• 0.1 mg / kg IV for children less than 10 kg

SIDE EFFECTS:

• Hypoxia

• Dizziness

• Drowsiness

• Blurred vision

• Headache

• Abdominal Pain / Constipation / Diarrhea

• Anxiety

• Malaise

• Bronchospasm

• Urinary retention

PRECAUTION:

• Use with caution in people with hepatic insufficiency