ETOMIDATE (AMIDATE)

CLASS:

• Hypnotic Anesthetic

ACTIONS:

• Non-barbiturate hypnotic that acts on GABA and depress activity of the RAS of the CNS with minimal cardiovascular and respiratory depressant effect

INDICATIONS:

• induction and maintenance of anesthesia to accommodate intubation

CONTRAINDICATION:

• Hypersensitivity

• Controversial use in septic shock

STANDARD PREP:

• 2 mg/ml

DOSE/ROUTE:

• 0.3 mg/kg IV

PEDS DOSE:

• See Hawaii S.O. & PALS Algorithm

SIDE EFFECTS:

• Hypertension or hypotension

• Arrhythmias

• Apnea or laryngospams

• N/V

• Myoclonic muscle movement

PRECAUTIONS:

• May cause cardiac depression in elderly

• Long term use can lead to adrenal suppression