MIDAZOLAM HYDROCHLORIDE (VERSED)

CLASSES:

• Short-acting benzodiazepine (Controlled Substance Schedule IV)

• Sedative hypnotic

ACTIONS:

• A benzodiazepine that enhances the action of gamma- aminobutyric acid (GABA), one of the major inhibitory neurotransmitters in the brain.

• Produces anxiolytic, hypnotic, anticonvulsant, muscle relaxant and amnestic effects

INDICATIONS:

• Premedication for tracheal intubation

• Seizures

CONTRAINDICATIONS:

• Shock

• Coma

• Alcohol intoxication

• Glaucoma

• Hypersensitivity

• Concomitant use of barbituates, alcohol, narcotics, or other CNS depressants

STANDARD PREP:

• 10 mg / 2 cc vial

DOSAGE/ROUTE:

• 0.06 mg / kg IV, may repeat same dose in increments to a max dose of 0.2 mg / kg

PEDIATRIC DOSE: See PALS Guidelines

SIDE EFFECTS:

• Hypotension

• Respiratory depression / arrest

• Laryngospasm, bronchospasm

• Headache

• Blurred vision, nystagmus

• Nausea & Vomiting

PRECAUTIONS:

• Provide continuous monitoring of respiratory and cardiac function

• Have resuscitative equipment and antagonist readily at hand.